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Phenotypes Associated with This Genotype
Genotype
MGI:5056476
Allelic
Composition
Sqstm1tm1.1Sral/Sqstm1+
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sqstm1tm1.1Sral mutation (0 available); any Sqstm1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• at 8 months, 1 of 4 mice exhibit focal osteolytic lesion mainly in the hind limb unlike wild-type mice
• at 12 months, 14 of 18 mice exhibit focal osteolytic lesion mainly in the hind limb unlike wild-type mice
• osteoclast formation from bone marrow macrophages is increased compared with wild-type cells
• within bone lesions

immune system
• osteoclast formation from bone marrow macrophages is increased compared with wild-type cells
• within bone lesions

hematopoietic system
• osteoclast formation from bone marrow macrophages is increased compared with wild-type cells
• within bone lesions

cellular
• osteoclast formation from bone marrow macrophages is increased compared with wild-type cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Paget Disease of Bone 2, Early-Onset; PDB2 602080 J:173755


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory