Mouse Genome Informatics
ht
    Sqstm1tm1.1Sral/Sqstm1+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
skeleton
• at 8 months, 1 of 4 mice exhibit focal osteolytic lesion mainly in the hind limb unlike wild-type mice
• at 12 months, 14 of 18 mice exhibit focal osteolytic lesion mainly in the hind limb unlike wild-type mice
• osteoclast formation from bone marrow macrophages is increased compared with wild-type cells
• within bone lesions

immune system
• osteoclast formation from bone marrow macrophages is increased compared with wild-type cells
• within bone lesions

hematopoietic system
• osteoclast formation from bone marrow macrophages is increased compared with wild-type cells
• within bone lesions

cellular
• osteoclast formation from bone marrow macrophages is increased compared with wild-type cells

Mouse Models of Human Disease
OMIM IDRef(s)
Paget Disease of Bone; PDB 602080 J:173755