Phenotypes Associated with This Genotype

Genotype
MGI:5056147

• Allelic Composition: Tg(Myh6-KDM4A)BZpl/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tg(Myh6-KDM4A)BZpl/0 mice exhibit cardiac hypertrophy in response to transverse aortic constriction

cardiovascular system

increased myocardial fiber size ( J:173908 )

• following transverse aortic constriction

increased heart weight ( J:173908 )

• following transverse aortic constriction

abnormal heart left ventricle morphology ( J:173908 )

• following transverse aortic constriction, mice exhibit increased left ventricular internal dimension in systole compared with wild-type mice

decreased cardiac muscle contractility ( J:173908 )

• following transverse aortic constriction

increased response of heart to induced stress ( J:173908 )

• following transverse aortic constriction, mice exhibit exacerbated hypertrophic response and loss of cardiac function compared with similarly treated wild-type mice

homeostasis/metabolism

increased response of heart to induced stress ( J:173908 )

• following transverse aortic constriction, mice exhibit exacerbated hypertrophic response and loss of cardiac function compared with similarly treated wild-type mice

muscle

increased myocardial fiber size ( J:173908 )

• following transverse aortic constriction

decreased cardiac muscle contractility ( J:173908 )

• following transverse aortic constriction

growth/size/body

increased heart weight ( J:173908 )

• following transverse aortic constriction