Mouse Genome Informatics
tg
    Tg(HTT*/EGFP)190Nn/0
involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• median survival is 21 weeks
• all die by 25 weeks of age

nervous system
• progression of neuropathology is more rapid compared to mice carrying Tg(HTT*/EGFP)150Nn

behavior/neurological
• chorea-like movements
• show irregular, jerky involuntary head movements at about 8 weeks of age
• rare
• fine tremor with onset at about 5-6 weeks of age
• progressive development of an ataxic gait that is severe and interferes with walking by 16 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:174269