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Phenotypes Associated with This Genotype
Genotype
MGI:5052380
Allelic
Composition
Tg(HTT*/EGFP)190Nn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 21 weeks
• all die by 25 weeks of age

nervous system
• progression of neuropathology is more rapid compared to mice carrying Tg(HTT*/EGFP)150Nn

behavior/neurological
• chorea-like movements
• show irregular, jerky involuntary head movements at about 8 weeks of age
• rare
• fine tremor with onset at about 5-6 weeks of age
• progressive development of an ataxic gait that is severe and interferes with walking by 16 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:174269


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory