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Phenotypes Associated with This Genotype
Genotype
MGI:5052380
Allelic
Composition
Tg(HTT*/EGFP)190Nn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 21 weeks
• all die by 25 weeks of age

nervous system
• progression of neuropathology is more rapid compared to mice carrying Tg(HTT*/EGFP)150Nn

behavior/neurological
• chorea-like movements
• show irregular, jerky involuntary head movements at about 8 weeks of age
• rare
• fine tremor with onset at about 5-6 weeks of age
• progressive development of an ataxic gait that is severe and interferes with walking by 16 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:174269


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory