mortality/aging
• despite normal Mendelian ratios at E18.5, no live born mice are recovered at P0
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respiratory system
• at E16.5 and E18.5, lungs exhibit aberrant clefts unlike in wild-type mice
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• mice exhibit decreased differentiation of epithelial type I, type II, and ciliated cells compared to in wild-type mice
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• at E18.5
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• at E16.5 and E18.5, lung cells exhibit increased in epithelial (Ttf1+) and mesenchymal (Ttf1-) cell proliferation compared with cells mice
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growth/size/body