Phenotypes Associated with This Genotype

Genotype
MGI:5052129

• Allelic Composition: Sart3^tm1.1Hbro/Sart3⁺; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:173259 )

• hematopoietic progenitor cells (HPCs) in the bone marrow and spleen are slowly or noncycling compared to in wild-type mice

• HPCs from 5-FU-treated mice are more protected than HPCs from wild-type mice

abnormal common myeloid progenitor cell morphology ( J:173259 )

• mice exhibit decreased colony forming units granulocyte, erythrocyte, macrophage, and megakaryocyte (CFU-GEMM) and granulocyte-macrophage (CFU-GM) compared with wild-type mice

• 5-FU-treated mice fail to exhibit a decrease in CFU-GM numbers by day 7 unlike similarly treated wild-type mice

• 5-FU-treated mice exhibit a 14.1-fold increase in CFU-GM at day 11 compared with a 5-fold elevation in similarly treated mice

• 5-FU-treated mice exhibit restored CFU-GEMM numbers after 11 days unlike similarly treated wild-type mice

decreased erythroid progenitor cell number ( J:173259 )

• mice exhibit decreased blast forming units erythrocyte (BFU-E) compared with wild-type mice

• 5-FU-treated mice exhibit a 1.9-fold increase in BFU-E unlike similarly treated wild-type mice

decreased hematopoietic stem cell number ( J:173259 )

• 5-FU-treated mice exhibit a decrease in long and short term repopulating hematopoietic stem cells compared with similarly treated wild-type mice