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Phenotypes Associated with This Genotype
Genotype
MGI:5051942
Allelic
Composition
Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa4tm1Bres mutation (1 available); any Apoa4 mutation (7 available)
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• impaired survival compared to wild-type mice and transgenic mice wild-type for Apoa4

nervous system
• accelerated deposition compared to transgenic mice wild-type for Apoa4
• large pyramidal neurons in cortical layer 5 and neurons in hippocampus contain more disrupted morphologies indicating enhanced neuron loss compared to transgenic mice wild-type for Apoa4
• loss of neurons is increased in areas of the cortex and CA1, CA3 of the hippocampus

behavior/neurological
• impaired spatial learning (slower decrease in escape latency during training in a morris water maze) compared to transgenic mice wild-type for Apoa4
• more time spent in the incorrect quadrant in a probe trial in a morris water maze compared to transgenic mice wild-type for Apoa4

homeostasis/metabolism
• accelerated deposition compared to transgenic mice wild-type for Apoa4

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:169682


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory