Phenotypes Associated with This Genotype

Genotype
MGI:5051941

• Allelic Composition: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:169682 )

• impaired survival compared to wild-type mice

• survive longer than transgenic mice that are also Apoa4 null

nervous system

amyloid beta deposits ( J:169682 )

neuron degeneration ( J:169682 )

homeostasis/metabolism

amyloid beta deposits ( J:169682 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:169682