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Phenotypes Associated with This Genotype
Genotype
MGI:5051941
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• impaired survival compared to wild-type mice
• survive longer than transgenic mice that are also Apoa4 null

nervous system

homeostasis/metabolism

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:169682


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory