Phenotypes for Cdkn2a Nf2 Ptgds MGI:5051643 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Nf2^tm2Gth/Nf2^tm2Gth Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1.1Brn mutation (1 available); any Cdkn2a mutation (59 available)
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (67 available)
Ptgds^{tm1.1(cre)Gvn} mutation (0 available); any Ptgds mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased meningioma incidence ( J:173718 )

• mice develop a slightly higher number of meningiomas (not statistically significant) relative to Cdkn2a-sufficient animals

mortality/aging

mortality/aging ( J:173718 )

N	• mice show similar survival/lifespan to Cdkn2a-sufficient animals

neoplasm

neoplasm ( J:173718 )

N	• no pituitary tumors are observed

increased meningioma incidence ( J:173718 )

• mice develop a slightly higher number of meningiomas (not statistically significant) relative to Cdkn2a-sufficient animals

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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