Phenotypes Associated with This Genotype

Genotype
MGI:5050418

• Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin; Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: B6.Cg-Prnp^tm2Edin Tg(APPswe,PSEN1dE9)85Dbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:160557 )

N • unlike transgenic mice wild-type for Prnp, life span is similar to wild-type in transgenic mice null for Prnp

behavior/neurological

behavior/neurological phenotype ( J:160557 )

N • unlike transgenic mice wild-type for Prnp, spatial learning and passive avoidance behavior are similar to controls in transgenic mice null for Prnp

nervous system

nervous system phenotype ( J:160557 )

N • unlike transgenic mice wild-type for Prnp, axon degeneration and synapse loss are not seen in transgenic mice null for Prnp

astrocytosis ( J:160557 )

• astrogliosis is similar to transgenic mice wild-type for Prnp

amyloid beta deposits ( J:160557 )

• plaque burdens are minimally different from transgenic mice wild-type for Prnp

homeostasis/metabolism

amyloid beta deposits ( J:160557 )

• plaque burdens are minimally different from transgenic mice wild-type for Prnp

cellular

astrocytosis ( J:160557 )

• astrogliosis is similar to transgenic mice wild-type for Prnp