mortality/aging
N |
• unlike transgenic mice wild-type for Prnp, life span is similar to wild-type in transgenic mice null for Prnp
|
behavior/neurological
N |
• unlike transgenic mice wild-type for Prnp, spatial learning and passive avoidance behavior are similar to controls in transgenic mice null for Prnp
|
nervous system
N |
• unlike transgenic mice wild-type for Prnp, axon degeneration and synapse loss are not seen in transgenic mice null for Prnp
|
• plaque burdens are minimally different from transgenic mice wild-type for Prnp
|
astrocytosis
(
J:160557
)
• astrogliosis is similar to transgenic mice wild-type for Prnp
|
homeostasis/metabolism
• plaque burdens are minimally different from transgenic mice wild-type for Prnp
|