Phenotypes Associated with This Genotype

Genotype
MGI:5050413

• Allelic Composition: Sorl1^tm1Tew/Sorl1^tm1Tew; Tg(APP695)3Dbo/0; Tg(PSEN1dE9)S9Dbo/0
• Genetic Background: involves: 129 * C3H/HeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:142501 )

• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta

• some of the largest differences in amyloid measures are detected in the cerebellum

homeostasis/metabolism

amyloid beta deposits ( J:142501 )

• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta

• some of the largest differences in amyloid measures are detected in the cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:142501