Phenotypes Associated with This Genotype

Genotype
MGI:5050120

• Allelic Composition: Rac1^tm1Tyb/Rac1^tm2Tyb; Tg(Ttr-cre)1Hadj/0
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:166095 )

• survive longer than germ line null mice, up to E8.25

embryo

abnormal anterior visceral endoderm cell migration ( J:166095 )

• migration of anterior visceral endoderm cells is disrupted

• defect in migration is not as severe as in germ line null mice probably due to the timing of cre expression

abnormal rostral-caudal axis patterning ( J:166095 )

• expression analysis indicates a defect in the initial specification of the AP axis in most embryos

embryonic-extraembryonic boundary constriction ( J:166095 )

• constriction at the boundary between embryonic and extraembryonic regions

abnormal extraembryonic endoderm formation ( J:173526 )

• visceral endoderm cells fail to form a border around the midline structures

craniofacial

abnormal craniofacial development ( J:166095 )

• abnormal headfolds at E7.5

cellular

abnormal anterior visceral endoderm cell migration ( J:166095 )

• migration of anterior visceral endoderm cells is disrupted

• defect in migration is not as severe as in germ line null mice probably due to the timing of cre expression