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Phenotypes Associated with This Genotype
Genotype
MGI:5014261
Allelic
Composition		 Leprtm1.1Chua/Lepr+
Tg(Gh1-cre)bKnmn/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Chua mutation (1 available); any Lepr mutation (121 available)
Tg(Gh1-cre)bKnmn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased somatotroph cell number ( J:173444 )
• in F1 generation males, a significant decrease in growth hormone-positive somatrophs is observed

nervous system
decreased somatotroph cell number ( J:173444 )
• in F1 generation males, a significant decrease in growth hormone-positive somatrophs is observed

reproductive system
reproductive system phenotype ( J:173444 )
N
• mice are fertile

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory