Phenotypes Associated with This Genotype

Genotype
MGI:5014258

• Allelic Composition: Mir21a^tm1Yoli/Mir21a^tm1Yoli
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:173464 )

• treatment with a skin carcinogenesis (DMBA/TPA) protocol results in a small but significant decrease in proliferating cell numbers compared to similarly treated control mice

decreased incidence of tumors by chemical induction ( J:173464 )

• decrease in the incidence of papillomas in a skin carcinogenesis assay

neoplasm

decreased incidence of tumors by chemical induction ( J:173464 )

• decrease in the incidence of papillomas in a skin carcinogenesis assay

abnormal tumor pathology ( J:173464 )

• papillomas that do form following a skin carcinogenesis (DMBA/TPA) protocol contain more apoptotic cells

integument

abnormal skin physiology ( J:173464 )

• increase in the number of apoptotic cells in the epidermis in the presence or absence of TPA treatment

• enhanced keratinocyte apoptosis