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Phenotypes Associated with This Genotype
Genotype
MGI:5014087
Allelic
Composition		 Pmltm1(PML/RARA)Ley/Pml+
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: BALB/cJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmltm1(PML/RARA)Ley mutation (1 available); any Pml mutation (91 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:172024 )
• in one tamoxifen-treated mouse
decreased hematopoietic stem cell number ( J:172024 )
• small decrease in tamoxifen-treated mice
abnormal hematopoietic stem cell physiology ( J:172024 )
• hematopoietic stem cells from tamoxifen-treated mice exhibit in vitro self-renewal compared with control cells
• however, tamoxifen-treated mice do not exhibit myeloproliferative disease

immune system
enlarged spleen ( J:172024 )
• in one tamoxifen-treated mouse

growth/size/body
enlarged spleen ( J:172024 )
• in one tamoxifen-treated mouse

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory