Mouse Genome Informatics
hm
    Cav1tm1Mls/Cav1tm1Mls
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• 20-25% reduction in cerebrovascular volume is observed in the hippocampi from young mice
• young (3-6 months) mice exhibit a reduction in the number of neurons in the CA1 region
• young mice exhibit areas of potential plaque development and disorganized astrocytes
• Fluoro-Jade B and Nissl staining of the CA1 region from 12 month old mice indicates increased neuronal degeneration as compared to age-matched controls
• young (3-6 months) mice exhibit a reduction in the number of neurons within the dentate gyrus
• increase in glia and glial scar formation within the dentate gyrus
• Fluoro-Jade B and Nissl staining of the CA1 region from 12 month old mice indicates increased neuronal degeneration as compared to age-matched controls
• tau deposits are elevated in hippocampal homogenates from young mice
• increase in glia and glial scar formation within the dentate gyrus
• astrocytes in young mice are disorganized as compared to young wild-type mice
• young mice exhibit a significant reduction in hippocampal synapses in comparison to age-matched wild-type mice, but similar to aged wild-type mice
• cytoskeletal architecture within dendrites is unorganized
• amyloid beta production is increased in the hippocampus of young mice
• young mice subjected to ischemic preconditioning prior to lethal ischemia lack the ability to protect CA1 neurons, a phenomenon observed in aged wild-type mice

cardiovascular system
• 20-25% reduction in cerebrovascular volume is observed in the hippocampi from young mice

other phenotype
• amyloid beta production is increased in the hippocampus of young mice

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:168335