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Phenotypes Associated with This Genotype
Genotype
MGI:5014041
Allelic
Composition
Cav1tm1Mls/Cav1tm1Mls
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1tm1Mls mutation (2 available); any Cav1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 20-25% reduction in cerebrovascular volume is observed in the hippocampi from young mice
• amyloid beta production is increased in the hippocampus of young mice
• young (3-6 months) mice exhibit a reduction in the number of neurons in the CA1 region
• young mice exhibit areas of potential plaque development and disorganized astrocytes
• Fluoro-Jade B and Nissl staining of the CA1 region from 12 month old mice indicates increased neuronal degeneration as compared to age-matched controls
• young (3-6 months) mice exhibit a reduction in the number of neurons within the dentate gyrus
• increase in glia and glial scar formation within the dentate gyrus
• Fluoro-Jade B and Nissl staining of the CA1 region from 12 month old mice indicates increased neuronal degeneration as compared to age-matched controls
• tau deposits are elevated in hippocampal homogenates from young mice
• increase in glia and glial scar formation within the dentate gyrus
• astrocytes in young mice are disorganized as compared to young wild-type mice
• young mice exhibit a significant reduction in hippocampal synapses in comparison to age-matched wild-type mice, but similar to aged wild-type mice
• cytoskeletal architecture within dendrites is unorganized
• young mice subjected to ischemic preconditioning prior to lethal ischemia lack the ability to protect CA1 neurons, a phenomenon observed in aged wild-type mice

cardiovascular system
• 20-25% reduction in cerebrovascular volume is observed in the hippocampi from young mice

homeostasis/metabolism
• amyloid beta production is increased in the hippocampus of young mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:168335


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory