Phenotypes for Gt(ROSA)26Sor Tg(Thy1-cre)1Dlam MGI:5013928 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm1(Flt1)Dlam}/Gt(ROSA)26Sor⁺ Tg(Thy1-cre)1Dlam/0
Genetic Background	involves: 129 * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Flt1)Dlam} mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
Tg(Thy1-cre)1Dlam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:172783 )

• 4 days following four paclitaxel injections to the hind paw, about 80% of mice respond to a pinprick stimulus compared to only 20% of wild type; overexpression of Flt1 is protective for sensory neurons to a distal neuropathy

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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