Phenotypes Associated with This Genotype

Genotype
MGI:5013649

• Allelic Composition: Panx1^tm1.2Vmd/Panx1^tm1.2Vmd
• Genetic Background: C57BL/6N-Panx1^tm1.2Vmd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:173213 )

N • macrophage exhibit normal assembly of caspase-1-activating inflammosome complexes

abnormal T cell physiology ( J:173213 )

• thymocytes cultured with dexamethasone to induce apoptosis exhibit reduced YO-PRO-1 dye uptake and fail to release ATP unlike similarly treated wild-type cells

• apoptotic thymocytes fail to recruit macrophages in a transwell migration assay unlike wild-type cells

• however, thymocyte apoptosis is normal

hematopoietic system

abnormal T cell physiology ( J:173213 )

• thymocytes cultured with dexamethasone to induce apoptosis exhibit reduced YO-PRO-1 dye uptake and fail to release ATP unlike similarly treated wild-type cells

• apoptotic thymocytes fail to recruit macrophages in a transwell migration assay unlike wild-type cells

• however, thymocyte apoptosis is normal