About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5013605
Allelic
Composition		 Cop1tm2.1Vmd/Cop1tm2.1Vmd
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cop1tm2.1Vmd mutation (0 available); any Cop1 mutation (42 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
prostate gland hyperplasia ( J:172653 )
• in 3 of 4 mice at 40 weeks of age
• in all mice at 52 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• low grade in 2 of 6 mice at 52 weeks of age
abnormal prostate gland physiology ( J:172653 )
• cells in the ventral and lateral prostate exhibit increased proliferation compared to in wild-type mice

neoplasm
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• low grade in 2 of 6 mice at 52 weeks of age

endocrine/exocrine glands
prostate gland hyperplasia ( J:172653 )
• in 3 of 4 mice at 40 weeks of age
• in all mice at 52 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• low grade in 2 of 6 mice at 52 weeks of age
abnormal prostate gland physiology ( J:172653 )
• cells in the ventral and lateral prostate exhibit increased proliferation compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory