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Phenotypes Associated with This Genotype
Genotype
MGI:5013565
Allelic
Composition		 Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased oocyte number ( J:173089 )
• very few oocytes survive until 6 weeks unlike in wild-type mice
abnormal female meiosis ( J:173089 )
• pseudo-sex-body-like formation is impaired compared to in wild-type cells
increased female germ cell apoptosis ( J:173089 )
• at P1, oocyte apoptosis rates are higher than in wild-type cells

reproductive system
decreased oocyte number ( J:173089 )
• very few oocytes survive until 6 weeks unlike in wild-type mice
abnormal female meiosis ( J:173089 )
• pseudo-sex-body-like formation is impaired compared to in wild-type cells
increased female germ cell apoptosis ( J:173089 )
• at P1, oocyte apoptosis rates are higher than in wild-type cells
arrest of spermatogenesis ( J:173089 )
• spermatocytes are eliminated in stage-IV tubules unlike in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory