Phenotypes Associated with This Genotype

Genotype
MGI:5013563

• Allelic Composition: Hormad1^tm1.2Atot/Hormad1^tm1.2Atot; Spo11^tm1Mjn/Spo11^tm1Mjn
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:173089 )

N • unlike in Spo11^tm1Sky homozygotes, oocyte numbers are normal

abnormal female meiosis ( J:173089 )

♀ • pseudo-sex-body-like formation is impaired compared to in wild-type cells

abnormal male meiosis ( J:173089 , J:292036 )

♂ • sex-body formation is impaired compared to in wild-type cells (J:173089)

♂ • absence of double-stranded breaks (DSBs) in spermatocytes (J:292036)

♂ • absence of BRME1 and RPA2 punctuate foci in spermatocytes (J:292036)

abnormal synaptonemal complex ( J:173089 )

• synaptonemal-complex defects are more severe than either single homozygote

cellular

abnormal female meiosis ( J:173089 )

♀ • pseudo-sex-body-like formation is impaired compared to in wild-type cells

abnormal male meiosis ( J:173089 , J:292036 )

♂ • sex-body formation is impaired compared to in wild-type cells (J:173089)

♂ • absence of double-stranded breaks (DSBs) in spermatocytes (J:292036)

♂ • absence of BRME1 and RPA2 punctuate foci in spermatocytes (J:292036)

abnormal synaptonemal complex ( J:173089 )

• synaptonemal-complex defects are more severe than either single homozygote