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Phenotypes Associated with This Genotype
Genotype
MGI:5013559
Allelic
Composition		 Hormad1tm1Atot/Hormad1tm1Atot
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad1tm1Atot mutation (0 available); any Hormad1 mutation (31 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173089 )
N
• unlike in Spo11tm1Sky homozygotes, oocyte numbers are normal
abnormal female meiosis ( J:173089 )
• pseudo-sex-body-like formation is impaired compared to in wild-type cells
abnormal male meiosis ( J:173089 )
• sex-body formation is impaired compared to in wild-type cells
abnormal synaptonemal complex ( J:173089 )
• synaptonemal-complex defects are more severe than either single homozygote

cellular
abnormal female meiosis ( J:173089 )
• pseudo-sex-body-like formation is impaired compared to in wild-type cells
abnormal male meiosis ( J:173089 )
• sex-body formation is impaired compared to in wild-type cells
abnormal synaptonemal complex ( J:173089 )
• synaptonemal-complex defects are more severe than either single homozygote

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory