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Phenotypes Associated with This Genotype
Genotype
MGI:5013390
Allelic
Composition
Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(SRF/VP16)Antu mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at P20, optic nerves exhibit disordered lamination in the direct circumference compared to in wild-type mice
• however, lamination in the periphery is normal
• with rossette formation
• in 80% of mice
• at P180 near the optic nerve in 60% of mice
• at P180, electroretinogram waveforms and parameters are different than in wild-type mice
• at P180, the ratio between the amplitudes of oscillatory potentials and b-waves is higher than in wild-type mice
• at P30 and P180, photopic b-wave and photopic 30 Hz flicker amplitudes are smaller than in wild-type mice
• at P180, scotopic and photopic oscillatory potential amplitudes are smaller than in wild-type mice
• at P180, scotopic a-wave and b-wave amplitudes are smaller than in wild-type mice
• at P180, scotopic and photopic oscillatory potential amplitudes are smaller than in wild-type mice

pigmentation
• in the eye at P180

growth/size/body

nervous system
• with rossette formation
• at P20, optic nerves exhibit disordered lamination in the direct circumference compared to in wild-type mice
• however, lamination in the periphery is normal

cardiovascular system


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory