Phenotypes Associated with This Genotype

Genotype
MGI:5009812

• Allelic Composition: Cd247^tm1Lov/Cd247^tm1Lov
• Genetic Background: B6.129S4-Cd247^tm1Lov/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

enlarged lateral ventricles ( J:66246 )

• 22% of P13 mice and 20% of adult mice have enlarged lateral ventricles

abnormal lateral geniculate nucleus morphology ( J:66246 )

• area of the ipsilateral projection is increased compared to controls

enhanced long-term potentiation ( J:66246 )

• LTP in response to tetanus is enhanced by approximately 248% as compared to wild type

abnormal long-term depression ( J:66246 )

• 900 pulses at 1 Hz enhances baseline LTD, but LTD is unchanged in wild-type

reduced long-term depression ( J:66246 )

• 900 pulses at 0.5 Hz does not induce significant LTD in contrast to wild-type response