Phenotypes Associated with This Genotype

Genotype
MGI:5009553

• Allelic Composition: Rb1^tm1Tyj/Rb1⁺; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuroblastoma incidence ( J:41126 )

• mutants exhibit a decreased latency and an increased incidence of tumors compared to single hemizygous Tg(Th-MYCN)41Waw mice, such that about 75% of mutants develop neuroblastomas by 10 months of age compared to 40% of single hemizygous Tg(Th-MYCN)41Waw mice

neoplasm

increased neuroblastoma incidence ( J:41126 )

• mutants exhibit a decreased latency and an increased incidence of tumors compared to single hemizygous Tg(Th-MYCN)41Waw mice, such that about 75% of mutants develop neuroblastomas by 10 months of age compared to 40% of single hemizygous Tg(Th-MYCN)41Waw mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769	OMIM:256700 OMIM:613013 OMIM:613014 OMIM:613015 OMIM:613016	J:41106