Mouse Genome Informatics
cx
     Rb1tm1Tyj/Rb1+
Tg(Th-MYCN)41Waw/0
involves: 129S2/SvPas * BALB/c * C57BL/6J
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
increased neuroblastoma incidence ( J:41126 )
• mutants exhibit a decreased latency and an increased incidence of tumors compared to single hemizygous Tg(Th-MYCN)41Waw mice, such that about 75% of mutants develop neuroblastomas by 10 months of age compared to 40% of single hemizygous Tg(Th-MYCN)41Waw mice

Mouse Models of Human Disease
 OMIM IDRef(s)
Neuroblastoma, Susceptibility to 256700 J:41106