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Phenotypes Associated with This Genotype
Genotype
MGI:5009549
Allelic
Composition
Tg(Th-MYCN)41Waw/0
Genetic
Background
involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-MYCN)41Waw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants develop thoracic paraspinous masses that histology indicates as neuroblastomas
• tumors show varying degrees of neuronal differentiation
• tumors show gains and losses of chromosomal regions; most commonly gained regions are on chromosomes 11 and 17, while loss is associated most often with chromosomes 5, 9, 16 and X
• Background Sensitivity: tumor penetrance on a background involving BALB/c and C57BL/6J is greater than in mutants with a BALB/c, C57BL/6J and FVB/N background

neoplasm
• mutants develop thoracic paraspinous masses that histology indicates as neuroblastomas
• tumors show varying degrees of neuronal differentiation
• tumors show gains and losses of chromosomal regions; most commonly gained regions are on chromosomes 11 and 17, while loss is associated most often with chromosomes 5, 9, 16 and X
• Background Sensitivity: tumor penetrance on a background involving BALB/c and C57BL/6J is greater than in mutants with a BALB/c, C57BL/6J and FVB/N background

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuroblastoma, Susceptibility to 256700 J:41126


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory