Mouse Genome Informatics
tg
    Tg(Th-MYCN)41Waw/0
involves: BALB/c * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• mutants develop thoracic paraspinous masses that histology indicates as neuroblastomas
• tumors show varying degrees of neuronal differentiation
• tumors show gains and losses of chromosomal regions; most commonly gained regions are on chromosomes 11 and 17, while loss is associated most often with chromosomes 5, 9, 16 and X
• Background Sensitivity: tumor penetrance on a background involving BALB/c and C57BL/6J is greater than in mutants with a BALB/c, C57BL/6J and FVB/N background

Mouse Models of Human Disease
OMIM IDRef(s)
Neuroblastoma, Susceptibility to 256700 J:41126