Phenotypes Associated with This Genotype

Genotype
MGI:5009271

• Allelic Composition: Tg(ACTB-SLC2A1)224Cwh/0
• Genetic Background: B6.Cg-Tg(ACTB-SLC2A1)224Cwh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

albuminuria ( J:160943 )

• urine albumin excretion is increased 140% by 26 weeks of age

increased renal glomerulus basement membrane thickness ( J:160943 )

• glomerular basement membrane thickness is increased by 8%

abnormal renal glomerulus morphology ( J:160943 )

• glomeruli have diffuse mesangial expansion, occasionally with nodular features

• mesangial matrix accumulation consists of excess type IV collagen and fibronectin

• type IV collagen is increased by 57%

• glomerular fibronectin is increased by 100%

• mean glomerular volume (MGV) is increased by 160%

• mean capillary diameter (MCD) is increased by 44%

• glomerular celllularity is decreased by 16%

glomerulosclerosis ( J:160943 )

• lesions progress to a moderate severity by 26 weeks of age

decreased kidney weight ( J:160943 )

• kidney weight/body weight ratio is reduced 20% by 26 weeks of age compared to controls

decreased renal tubule number ( J:160943 )

• mice have 23% fewer cortical renal tubules/unit area

homeostasis/metabolism

increased circulating creatinine level ( J:160943 )

• plasma creatinine concentration is increased 25% at 26 weeks of age

• BUN level is similar to controls

albuminuria ( J:160943 )

• urine albumin excretion is increased 140% by 26 weeks of age

cellular

increased cellular glucose import ( J:160943 )

• 3.7 fold increase in glomerular glucose uptake rate as compared to controls

• 1.8 fold increase in glomerular mesangial cell glucose uptake rate