Phenotypes Associated with This Genotype

Genotype
MGI:5009221

• Allelic Composition: Ndrg1^str/Ndrg1^str
• Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:172770 )

• some mice die between 1 to 10 months

behavior/neurological

limb grasping ( J:172770 )

• from 5 weeks of age

• progressively increases in severity with age until 15 to 20 weeks

tremors ( J:172770 )

• from 5 weeks of age

• progressively increases in severity with age until 15 to 20 weeks

weakness ( J:172770 )

• in the hindlimb

hindlimb paralysis ( J:172770 )

• at 15 to 20 weeks, mice exhibit severe flaccid paralysis in hind limbs unlike wild-type mice

nervous system

demyelination ( J:172770 )

• occasional at 3 weeks of age

• extensive at 5 weeks of age

• more severe than in Ndrg1^tm1Myta homozygotes

decreased nerve conduction velocity ( J:172770 )

• starting at 5 weeks of age, mice exhibit decreased motor nerve conduction velocities with rapid deterioration with age unlike in wild-type mice

• at 16 weeks of age, sensory nerve conduction velocity is decreased compared to in wild-type mice

muscle

skeletal muscle atrophy ( J:172770 )

• in the hind leg

growth/size/body

decreased body size ( J:172770 )

vision/eye

cataract ( J:172770 )

• as young as 3 weeks of age