Phenotypes Associated with This Genotype

Genotype
MGI:5008746

• Allelic Composition: Gy/Y
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:8335 )

♂ • sudden

reproductive system

oligozoospermia ( J:8335 )

♂

decreased testis weight ( J:8335 )

♂

male infertility ( J:8335 )

♂

skeleton

abnormal tooth morphology ( J:8335 )

♂

abnormal long bone morphology ( J:8335 )

♂ • soft

abnormal fibula morphology ( J:8335 )

♂ • uneven thickness

decreased length of long bones ( J:8335 )

♂

increased diameter of long bones ( J:8335 )

♂

abnormal rib morphology ( J:8335 )

♂ • uneven thickness

splayed ribs ( J:8335 )

♂

abnormal osteoid morphology ( J:8335 )

♂ • osteoid seams are widened compared to in wild-type mice

osteomalacia ( J:8335 )

♂

hearing/vestibular/ear

abnormal ear morphology ( J:8335 )

♂ • mice exhibit abnormal vestibular sense organs compared with wild-type mice

abnormal organ of Corti morphology ( J:8335 )

♂

cochlear hair cell degeneration ( J:8335 )

♂

detached tectorial membrane ( J:8335 )

♂

abnormal semicircular canal morphology ( J:8335 )

♂ • stenotic

utricular degeneration ( J:8335 )

♂

vestibular saccular degeneration ( J:8335 )

♂

deafness ( J:64263 )

♂

behavior/neurological

absent pinna reflex ( J:8335 )

♂

impaired righting response ( J:8335 )

♂ • absent

head shaking ( J:8335 )

♂

hyperactivity ( J:8335 )

♂

circling ( J:64263 , J:8335 )

♂ (J:64263)

♂ (J:8335)

vision/eye

blepharitis ( J:8335 )

♂

abnormal eyelid morphology ( J:8335 )

♂

growth/size/body

abnormal head morphology ( J:8335 )

♂

abnormal tooth morphology ( J:8335 )

♂

decreased body size ( J:8335 )

♂ • at P1

decreased body weight ( J:8335 )

♂

homeostasis/metabolism

decreased circulating phosphate level ( J:8335 )

♂

increased circulating alkaline phosphatase level ( J:8335 )

♂

abnormal urine nucleotide level ( J:8335 )

♂ • urinary cAMP is increased compared to in wild-type mice

increased urine phosphate level ( J:8335 )

♂

immune system

blepharitis ( J:8335 )

♂

nervous system

cochlear hair cell degeneration ( J:8335 )

♂

abnormal cochlear nerve morphology ( J:8335 )

♂

renal/urinary system

abnormal urine nucleotide level ( J:8335 )

♂ • urinary cAMP is increased compared to in wild-type mice

increased urine phosphate level ( J:8335 )

♂

craniofacial

abnormal tooth morphology ( J:8335 )

♂

endocrine/exocrine glands

decreased testis weight ( J:8335 )

♂

limbs/digits/tail

abnormal fibula morphology ( J:8335 )

♂ • uneven thickness

cellular

oligozoospermia ( J:8335 )

♂