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Phenotypes Associated with This Genotype
Genotype
MGI:5008740
Allelic
Composition
Tg(PDGFB-UCHL1*I93M)HWada/?
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decrease in striatal dopamine concentration (J:128045)
• decrease in striatal dopamine concentration (J:128045)
• cytoplasmic inclusions in the form of large aggregates are seen in the remain portion of the substantia nigra at 20 weeks of age (J:128045)
• these inclusions are ubiqutin and UCHL1 positive but SNCA negative (J:128045)
• electron dense-core vesicles are seen in the cytoplasm of about 30% of nigral neurons (J:128045)
• cytoplasmic inclusions in the form of large aggregates are seen in the remain portion of the substantia nigra at 20 weeks of age (J:128045)
• these inclusions are ubiqutin and UCHL1 positive but SNCA negative (J:128045)
• electron dense-core vesicles are seen in the cytoplasm of about 30% of nigral neurons (J:128045)
• nigro-striatal fibers show reduced TH-immunoreactivity (J:128045)
• nigro-striatal fibers show reduced TH-immunoreactivity (J:128045)
• 30% reduction in TH-positive neurons at 20 weeks of age but not at 12 weeks of age, compared to non-transgenic controls (J:128045)
• 30% reduction in TH-positive neurons at 20 weeks of age but not at 12 weeks of age, compared to non-transgenic controls (J:128045)

behavior/neurological
• increase in locomotion during the dark phase at 11-13 weeks of age in the home cage (J:128045)
• increase in locomotion during the dark phase at 11-13 weeks of age in the home cage (J:128045)
• modest but significant decrease in activity during the dark phase at 19-21 weeks of age (J:128045)
• modest but significant decrease in activity during the dark phase at 19-21 weeks of age (J:128045)

homeostasis/metabolism
• decrease in striatal dopamine concentration (J:128045)
• decrease in striatal dopamine concentration (J:128045)


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory