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Phenotypes Associated with This Genotype
involves: C57BL/6J
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decrease in striatal dopamine concentration
• cytoplasmic inclusions in the form of large aggregates are seen in the remain portion of the substantia nigra at 20 weeks of age
• these inclusions are ubiqutin and UCHL1 positive but SNCA negative
• electron dense-core vesicles are seen in the cytoplasm of about 30% of nigral neurons
• nigro-striatal fibers show reduced TH-immunoreactivity
• 30% reduction in TH-positive neurons at 20 weeks of age but not at 12 weeks of age, compared to non-transgenic controls

• increase in locomotion during the dark phase at 11-13 weeks of age in the home cage
• modest but significant decrease in activity during the dark phase at 19-21 weeks of age

• decrease in striatal dopamine concentration

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory