Phenotypes Associated with This Genotype

Genotype
MGI:5008468

• Allelic Composition: Tg(LRRK2*G2019S)1Mjfa/0
• Genetic Background: FVB-Tg(LRRK2*G2019S)1Mjfa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:172418 )

• primary neurons exhibit reduced neuron outgrowth and branching compared with control neurons

• however, indolocarbazole-treatment partially rescues outgrowth

abnormal neurite morphology ( J:172418 )

• primary neurons exhibit reduced neuron outgrowth and branching compared with control neurons

• however, indolocarbazole-treatment partially rescues outgrowth

cellular

abnormal axon extension ( J:172418 )

• primary neurons exhibit reduced neuron outgrowth and branching compared with control neurons

• however, indolocarbazole-treatment partially rescues outgrowth