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Phenotypes Associated with This Genotype
Genotype
MGI:5008416
Allelic
Composition		 Itgb8tm1Lfr/Itgb8tm1Lfr
Genetic
Background		 involves: 129/Sv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb8tm1Lfr mutation (1 available); any Itgb8 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain vasculature morphology ( J:136106 )
• in newborn mice, brain vessels are enlarged and hyperplastic compared to in control mice
enlarged brain ventricles ( J:136106 )
• enlarged ventricles

cardiovascular system
abnormal brain vasculature morphology ( J:136106 )
• in newborn mice, brain vessels are enlarged and hyperplastic compared to in control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory