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Phenotypes Associated with This Genotype
Genotype
MGI:5007933
Allelic
Composition		 Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mefvtm5.1(MEFV)Chae mutation (0 available); any Mefv mutation (44 available)
Nlrp3tm1Tsc mutation (0 available); any Nlrp3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased interleukin-1 beta secretion ( J:172117 )
• bone marrow CD11b+ cells and bone marrow-derived dendritic cells secrete IL1beta when stimulated with LPS alone, unlike wild-type cells
increased inflammatory response ( J:172117 )
• mice exhibit inflammatory phenotypes observed in Mefvtm5.1(MEFV)Chae homozygotes

growth/size/body
decreased body weight ( J:172117 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory