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Phenotypes Associated with This Genotype
Genotype
MGI:5007931
Allelic
Composition		 Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mefvtm5.1(MEFV)Chae mutation (0 available); any Mefv mutation (44 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:172117 )
• activated T cells secrete less cytokines than in activated T cells from Mefvtm5.1(MEFV)Chae homozygotes but more cytokines than in actiavted T cells from wild-type
• activated T cells exhibit increased secretion of IL1b, IL2, IL4, IL5, IL9, IL10, IL12b, IL12, IL13, IL17, IFN-gamma, RANTES, G-CSF, MIP1alpha, KC, GM-CSF, MCP-1, and MIP1beta compared with activated T cells from wild-type mice
increased interferon-gamma secretion ( J:172117 )
• in activated T cells
increased interleukin-10 secretion ( J:172117 )
• in activated T cells
increased interleukin-12 secretion ( J:172117 )
• in activated T cells
increased interleukin-13 secretion ( J:172117 )
• in activated T cells
increased interleukin-17 secretion ( J:172117 )
• in activated T cells
increased interleukin-2 secretion ( J:172117 )
• in activated T cells
increased interleukin-4 secretion ( J:172117 )
• in activated T cells
increased interleukin-5 secretion ( J:172117 )
• in activated T cells
increased interleukin-9 secretion ( J:172117 )
• in activated T cells
increased inflammatory response ( J:172117 )
• mice exhibit inflammatory phenotypes observed in Mefvtm5.1(MEFV)Chae homozygotes

growth/size/body
decreased body weight ( J:172117 )

homeostasis/metabolism

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory