Mouse Genome Informatics
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    Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
B6.129S6-Mefvtm5.1(MEFV)Chae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die between 2 and 3 weeks of age

immune system
• mice exhibit increased CD11b+ cells in the spleen, bone marrow, peripheral blood, and lymph nodes compared with wild-type mice
• with infiltration of inflammatory cells
• activated T cells exhibit increased secretion of IL1a, IL1b, IL2, IL3, IL4, IL5, IL9, IL10, IL12b, IL12, IL13, IL17, IFN-gamma, G-CSF, MIP1alpha, KC, GM-CSF, MCP-1, and MIP1beta compared with activated T cells from wild-type mice
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• mice exhibit inflammation in the skin, liver, joint, and bone marrow with infiltration of leukocytes (mainly neutrophils and macrophages) compared with wild-type mice
• inflammatory phenotypes are more severe than in Mefvtm3.1(MEFV)Chae homozygotes and Mefvtm4.1(MEFV)Chae homozygotes

growth/size
• as early as 1 week of age

homeostasis/metabolism

integument
• as early as 1 week of age

liver/biliary system

skeleton

hematopoietic system
• mice exhibit increased CD11b+ cells in the spleen, bone marrow, peripheral blood, and lymph nodes compared with wild-type mice
• with infiltration of inflammatory cells

Mouse Models of Human Disease
OMIM IDRef(s)
Familial Mediterranean Fever; FMF 249100 J:172117