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Phenotypes Associated with This Genotype
Genotype
MGI:5007795
Allelic
Composition		 Krastm5Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (7 available); any Gt(ROSA)26Sor mutation (1095 available)
Krastm5Tyj mutation (2 available); any Kras mutation (88 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sarcoma incidence ( J:172206 )
• mice treated with flp-expressing adenovirus and tamoxifen on the same day exhibit sarcomas
• however, delayed tamoxifen-treatment reduces sarcoma formation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory