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Phenotypes Associated with This Genotype
Genotype
MGI:5007681
Allelic
Composition		 Agtr1atm1.1Cof/Agtr1atm1.1Cof
Hprt1tm1(Pck1-cre)Vhh/Hprt1+
Genetic
Background		 involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1.1Cof mutation (0 available); any Agtr1a mutation (40 available)
Hprt1tm1(Pck1-cre)Vhh mutation (0 available); any Hprt1 mutation (1274 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased systemic arterial systolic blood pressure ( J:172240 )
• decreased during both the night and day
• responses to high salt diet and vasoconstrictors are similar to wild-type controls

renal/urinary system
abnormal renal water reabsorption ( J:172240 )
• absolute rates of proximal fluid reabsorption are reduced
• fractional reabsorption rates, corrected for single nephron glomerular filtration rate, are reduced
decreased renal glomerular filtration rate ( J:172240 )
• decrease in single nephron glomerular filtration rate in the proximal tubules

homeostasis/metabolism
abnormal renal water reabsorption ( J:172240 )
• absolute rates of proximal fluid reabsorption are reduced
• fractional reabsorption rates, corrected for single nephron glomerular filtration rate, are reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory