Mouse Genome Informatics
tg
    Tg(Mov1/Tyr)OVE876BPay/Tg(Mov1/Tyr)OVE876BPay
FVB/N-Tg(Mov1/Tyr)OVE876BPay
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• females are hyperactive but do not develop perseverative circling (J:167614)
• pups exhibit a shift in separation-induced ultrasonic vocalization pattern, with female pups exhibiting an approximate 2 day shift in the ultrasonic vocalization development curve, such that females do not persistently decrease their vocalizations from peak levels until P10 compared to P8 in wild-type females (J:167614)
• young females are more likely to have a seizure when subjected to a loud sound stimulus compared to wild-type mice, however no spontaneous seizure activity is seen (J:167614)

integument
• females exhibit a salt-and-pepper pigmentation pattern (J:167614)

nervous system
• young females are more likely to have a seizure when subjected to a loud sound stimulus compared to wild-type mice, however no spontaneous seizure activity is seen (J:167614)
• across a range of 17-45 days of age, females exhibit a prepulse inhibition deficit indicating impaired sensorimotor gating (J:167614)
• across a range of 17-45 days of age, females exhibit a prepulse inhibition deficit but no difference in acoustic startle response (J:167614)

pigmentation
• females exhibit a salt-and-pepper pigmentation pattern (J:167614)

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:167614