Phenotypes for Atp11c MGI:5006842 MGI Mouse

immune system phenotype ( J:171925 , J:185495 )

N	• mice exhibit normal allelic exclusion at the immunoglobulin heavy-chain locus (J:171925) • mice exhibit normal fetal B cell lymphopoiesis (J:171925) • mice exhibit a normal response to NP-Ficoll and recombinant Semliki Forest virus (SFV) encoded antigen (J:185495)

arrested B cell differentiation ( J:171925 )

• mice exhibit cell-intrinsic failure of adult B lymphopoiesis unlike in wild-type mice

decreased B cell number ( J:171925 , J:185495 )

• the percentage of CD19+ B cells in the blood is reduced compared to in wild-type mice (J:171925)

• however, mice exhibit normal numbers of marginal zone B cells and Thy-1.2+ cells (J:171925)

• B cell deficiency (J:185495)

decreased immature B cell number ( J:171925 )

• mice exhibit fewer pre-pro-B cells to pro-B cells compared with wild-type mice

decreased transitional stage B cell number ( J:171925 )

• in the spleen

decreased transitional stage T1 B cell number ( J:171925 )

decreased transitional stage T2 B cell number ( J:171925 )

decreased transitional stage T3 B cell number ( J:171925 )

decreased B-1 B cell number ( J:171925 )

• 3-fold in the peritoneal cavity

decreased B-2 B cell number ( J:171925 )

• 10-fold in the peritoneal cavity

absent follicular B cells ( J:171925 )

decreased IgA level ( J:171925 )

decreased IgG1 level ( J:171925 )

• 50% less high-affinity IgG1 antibodies in response to alum-precipitated NP-CGG

decreased IgM level ( J:171925 )

• 50% less NP-specific IgM antibodies in response to NP-ficoll

increased circulating bilirubin level ( J:171925 )