Phenotypes Associated with This Genotype

Genotype
MGI:5006708

• Allelic Composition: Notch1^sot/Notch1^sot
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Thin neural tube in E9.5-10.5 Notch1^sot/Notch1^sot embryos

cardiovascular system

abnormal vascular development ( J:171522 )

• at E9.5-10.5, mutants display constricted capillaries or microvascular networks

craniofacial

small pharyngeal arch ( J:171522 )

• at E9.5, the pharyngeal arches are reduced in size compared to controls

embryo

small pharyngeal arch ( J:171522 )

• at E9.5, the pharyngeal arches are reduced in size compared to controls

decreased embryo size ( J:171522 )

• at E9.5, mutant embryos are one half to two-thirds the size of control littermates

growth/size/body

decreased embryo size ( J:171522 )

• at E9.5, mutant embryos are one half to two-thirds the size of control littermates

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171522 )

• embryos die by E11

nervous system

abnormal nervous system development ( J:171522 )

• at E10.5, mutants exhibit only rudimentary neuronal differentiation within the cranial ganglia and a complete lack of neuronal differentiation within the midbrain

abnormal trigeminal ganglion morphology ( J:171522 )

• in E8.5-9.5 embryos, the trigeminal ganglion is abnormally shaped and the Sox10 positive neural crest cell population within the forming ganglion is disorganized and dispersed rather than forming a tight coalescence as it does in controls