Phenotypes Associated with This Genotype

Genotype
MGI:5003504

• Allelic Composition: Tg(Thy1-APP^SL)28Lpr/0
• Genetic Background: B6.Cg-Tg(Thy1-APP^SL)28Lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:145588 )

• enhanced lethality at young ages (less than 4 months of age)

behavior/neurological

increased anxiety-related response ( J:145588 )

• spend more time in the closed arms of an elevated plus maze at 15 months of age compared to age matched controls

impaired coordination ( J:145588 )

• cross fewer segments and show a reduced latency to fall in a stationary beam test at 15 months of age

decreased grip strength ( J:145588 )

• significant decrease in latency to fall in a wire grid assay at 3 and 15, but not at 6, months of age

• significant decrease in latency to fall in a coat hanger assay at 15 months of age

decreased locomotor activity ( J:145588 )

• at 3, 6, and 15 months of age in an open field test

• activity decreases with age

nervous system

amyloid beta deposits ( J:145588 )

increased brain size ( J:145588 )

• increase in brain length but not weight

growth/size/body

decreased body weight ( J:145588 )

• from 3 to 15 months of age

homeostasis/metabolism

amyloid beta deposits ( J:145588 )