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Phenotypes Associated with This Genotype
Genotype
MGI:5003501
Allelic
Composition
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Lpr mutation (0 available); any Psen1 mutation (22 available)
Tg(Thy1-APPSL)28Lpr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• some plaques are detected at 2 months of age in the cervical spinal cord and plaques increase with age (J:128106)
• plaque formation is higher in the cervical spinal cord compared to the thoracic and lumbar regions (J:128106)
• plaques are almost exclusively found in the gray matter (J:128106)
• some plaques are detected at 2 months of age in the cervical spinal cord and plaques increase with age (J:128106)
• plaque formation is higher in the cervical spinal cord compared to the thoracic and lumbar regions (J:128106)
• plaques are almost exclusively found in the gray matter (J:128106)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• significant plaque formation is detected in the frontal cortex by 2 months of age (J:146342)
• from 6 to 12 months of age plaques become more densely packed (J:146342)
• significant plaque formation is detected in the frontal cortex by 2 months of age (J:146342)
• from 6 to 12 months of age plaques become more densely packed (J:146342)
• amyloid beta plaques form but no intracellular aggregates are seen (J:146342)
• numerous plaques form between 2 and 6 months of age and the pathology increases with age (J:146342)
• unlike in the frontal cortex, no neuronal loss is detected in the thalamus (J:146342)
• amyloid beta plaques form but no intracellular aggregates are seen (J:146342)
• numerous plaques form between 2 and 6 months of age and the pathology increases with age (J:146342)
• unlike in the frontal cortex, no neuronal loss is detected in the thalamus (J:146342)
• the granule cell layer is less densely packed at 12 months of age compared to 2 months of age (J:139736)
• the granule cell border is often frayed (J:139736)
• ectopic cells that are often orientated towards extracellular amyloid deposits can be detected at 2 months of age (J:139736)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• decrease in the number of dentate gyrus granule cells at 12 months of age (J:139736)
• the granule cell layer is less densely packed at 12 months of age compared to 2 months of age (J:139736)
• the granule cell border is often frayed (J:139736)
• ectopic cells that are often orientated towards extracellular amyloid deposits can be detected at 2 months of age (J:139736)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• decrease in the number of dentate gyrus granule cells at 12 months of age (J:139736)
• decrease in the number of dentate gyrus granule cells at 12 months of age (J:139736)
• decrease in the number of dentate gyrus granule cells at 12 months of age (J:139736)
• massive intra- and extra-cellular amyloid beta deposits are detected in the frontal cortex at as early as 1.5 months of age, before significant plaque formation is detected (J:146342)
• by 6 months of age intracellular accumulations are no longer a prominent pathological feature (J:146342)
• a 28% and 35% loss of neurons is seen in the frontal cortex at 6 and 12 months of age, respectively, compared to age-matched controls (J:146342)
• frontal cortex volume is reduced compared to controls at 6 and 12 months of age (J:146342)
• massive intra- and extra-cellular amyloid beta deposits are detected in the frontal cortex at as early as 1.5 months of age, before significant plaque formation is detected (J:146342)
• by 6 months of age intracellular accumulations are no longer a prominent pathological feature (J:146342)
• a 28% and 35% loss of neurons is seen in the frontal cortex at 6 and 12 months of age, respectively, compared to age-matched controls (J:146342)
• frontal cortex volume is reduced compared to controls at 6 and 12 months of age (J:146342)
• thickened and irregularly shaped neurites are seen in the medulla at 14 months of age (J:128106)
• thickened and irregularly shaped neurites are seen in the medulla at 14 months of age (J:128106)
• axonal spheroids are detected in pons and cortical areas at 6 months of age and in the spinal cord mostly along the anterior margin of the ventral horn and less frequently in the intermediolateral and dorsal horn (J:128106)
• at 10 and 14 months of age axonal spheroids are detected in pons, cortex, medulla, midbrain, hippocampus, corpus callosum and striatum (J:128106)
• larger axonal varicosities are seen in the medulla at 14 months of age (J:128106)
• large axonal dilatations are localized in white matter fiber tracts in close vicinity to the ventral horn in the spinal cord (J:128106)
• axonal spheroids are detected in pons and cortical areas at 6 months of age and in the spinal cord mostly along the anterior margin of the ventral horn and less frequently in the intermediolateral and dorsal horn (J:128106)
• at 10 and 14 months of age axonal spheroids are detected in pons, cortex, medulla, midbrain, hippocampus, corpus callosum and striatum (J:128106)
• larger axonal varicosities are seen in the medulla at 14 months of age (J:128106)
• large axonal dilatations are localized in white matter fiber tracts in close vicinity to the ventral horn in the spinal cord (J:128106)
• dilated axons often display thinned or focally absent myelin sheaths (J:128106)
• increased deposition of myelin ovoids in the white matter (J:128106)
• dilated axons often display thinned or focally absent myelin sheaths (J:128106)
• increased deposition of myelin ovoids in the white matter (J:128106)
• a 28% and 35% loss of neurons is seen in the frontal cortex at 6 and 12 months of age, respectively, compared to age-matched controls (J:146342)
• a 28% and 35% loss of neurons is seen in the frontal cortex at 6 and 12 months of age, respectively, compared to age-matched controls (J:146342)

homeostasis/metabolism
• significant decrease in plasma cholesterol between 2 and 6 months of age that is not seen in wild-type controls or either single transgenic mice (J:128243)
• significant decrease in plasma cholesterol between 2 and 6 months of age that is not seen in wild-type controls or either single transgenic mice (J:128243)
• basal cholesterol levels are increase compared to wild-type controls probably as a result of differences in strain background (J:128243)
• basal cholesterol levels are increase compared to wild-type controls probably as a result of differences in strain background (J:128243)
• some plaques are detected at 2 months of age in the cervical spinal cord and plaques increase with age (J:128106)
• plaque formation is higher in the cervical spinal cord compared to the thoracic and lumbar regions (J:128106)
• plaques are almost exclusively found in the gray matter (J:128106)
• some plaques are detected at 2 months of age in the cervical spinal cord and plaques increase with age (J:128106)
• plaque formation is higher in the cervical spinal cord compared to the thoracic and lumbar regions (J:128106)
• plaques are almost exclusively found in the gray matter (J:128106)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• significant plaque formation is detected in the frontal cortex by 2 months of age (J:146342)
• from 6 to 12 months of age plaques become more densely packed (J:146342)
• significant plaque formation is detected in the frontal cortex by 2 months of age (J:146342)
• from 6 to 12 months of age plaques become more densely packed (J:146342)

behavior/neurological
• at 10 and 14 months of age (J:128106)
• at 10 and 14 months of age (J:128106)
• impaired performance in a balance beam test at 10 and 14 months of age (J:128106)
• impaired performance in a balance beam test at 10 and 14 months of age (J:128106)

growth/size/body
• at 10 and 14 months of age compared to mutant mice not carrying the transgene (J:128106)
• at 10 and 14 months of age compared to mutant mice not carrying the transgene (J:128106)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:128106


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory