Phenotypes Associated with This Genotype

Genotype
MGI:5003462

• Allelic Composition: Tg(Hmgcr-PSEN1*M146L)#Lpr/0; Tg(Thy1-APPLon)2Vln/0
• Genetic Background: involves: C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:86694 )

• plaques are seen at 6 months of age

• as soon as detectable, a large number of deposits have a fibrillar conformation

homeostasis/metabolism

amyloid beta deposits ( J:86694 )

• plaques are seen at 6 months of age

• as soon as detectable, a large number of deposits have a fibrillar conformation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652	OMIM:104300 OMIM:502500 OMIM:604154 OMIM:608907	J:86694