About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5003460
Allelic
Composition
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 17 months of age (J:99507)
• levels of SDS-soluble amyloid beta protein are higher in females than in males at 3 months of age
• age-related decline in mean synaptic bouton densities
• age-related decline in mean synaptic bouton densities in area CA1?2
• clusters of swollen and abnormally distorted neuritic profiles are seen
• age-related decline in mean synaptic bouton densities within the hippocampal molecular cell layer and stratum radiatum of area CA1?2
• elevated levels of lipid peroxidation products in brain homogenates in females at 3 months of age and in males and females at 12 months of age
• reduced levels of antioxidant enzymes at 3 and 12 months of age
• impaired mitochondrial function

cellular
• mitochondrial membrane potentials and ATP levels are reduced in dissociated brain cells at 3 months of age
• inhibition of complex IV and significantly reduced cytochrome c oxidase activity in cerebral isolated mitochondria
• state 3 and state 4 respiration are significantly reduced in freshly isolated cerebral mitochondria at 17 months of age

homeostasis/metabolism
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 17 months of age (J:99507)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:86694 , J:99507


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/13/2016
MGI 6.05
The Jackson Laboratory