Mouse Genome Informatics
tg
    Tg(Thy1-APPSL)28Lpr/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• levels of SDS-soluble amyloid beta protein are higher in females than in males at 3 months of age
• age-related decline in mean synaptic bouton densities
• age-related decline in mean synaptic bouton densities in area CA1?2
• clusters of swollen and abnormally distorted neuritic profiles are seen
• age-related decline in mean synaptic bouton densities within the hippocampal molecular cell layer and stratum radiatum of area CA1?2
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 17 months of age (J:99507)
• elevated levels of lipid peroxidation products in brain homogenates in females at 3 months of age and in males and females at 12 months of age
• reduced levels of antioxidant enzymes at 3 and 12 months of age
• impaired mitochondrial function

cellular
• mitochondrial membrane potentials and ATP levels are reduced in dissociated brain cells at 3 months of age
• inhibition of complex IV and significantly reduced cytochrome c oxidase activity in cerebral isolated mitochondria
• state 3 and state 4 respiration are significantly reduced in freshly isolated cerebral mitochondria at 17 months of age

other phenotype
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 17 months of age (J:99507)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:86694 , J:99507