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Phenotypes Associated with This Genotype
Genotype
MGI:5003459
Allelic
Composition
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 4.5 and 17 months of age (J:99507)
• abundant amyloid beta neuropil deposits in hippocampal and cortical areas in aged mice (J:128243)
• non-corrected intracranial and brain volumes are reduced compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics at 10 weeks of age
• corrected brain volumes are strongly decreased with age
• in aged mice compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• significant increase in brain length with age compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• surface area of the internal capsule does not increase with age unlike in Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• decrease in thickness of the caudal corpus callosum with age
• decrease in fornix diameter in aged mice
• age-related decline in mean synaptic bouton densities within the stratum lucidum of area CA3
• age-related decline in mean synaptic bouton densities and in mean volume
• age-related decline in mean synaptic bouton densities in area CA1?2
• clusters of swollen and abnormally distorted neuritic profiles are seen
• age-related decline in mean synaptic bouton densities within the hippocampal molecular cell layer, stratum lucidum of area CA3, and stratum radiatum of area CA1?2
• global brain atrophy in aged mice

homeostasis/metabolism
• significant decrease in plasma cholesterol between 3 and 13 months of age that is not seen in wild-type controls
• plasma cholesterol levels are reduced compared to wild-type controls at 13 months of age but not at 3 months of age
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 4.5 and 17 months of age (J:99507)
• abundant amyloid beta neuropil deposits in hippocampal and cortical areas in aged mice (J:128243)

growth/size/body
• brain weight to body weight ratio is increased compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics at 24 months of age
• in aged mice compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:86694 , J:99507


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory