Phenotypes Associated with This Genotype

Genotype
MGI:5002531

• Allelic Composition: Gabra2^tm1.1Geh/Gabra2^tm1.1Geh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:171967 )

• despite normal representation prior to birth, mice are under-represented at weaning

behavior/neurological

enhanced behavioral response to anesthetic ( J:171967 )

• isoflurane-treated mice exhibit increased sedation, immobility, and recovery time compared with similarly treated wild-type mice

• however, response to halothane is normal and additional backcrossing to C57BL/6 restores recovery from isoflurane

enhanced contextual conditioning behavior ( J:171967 )

enhanced cued conditioning behavior ( J:171967 )

nervous system

abnormal miniature inhibitory postsynaptic currents ( J:171967 )

• the average decay time constant of miniature inhibitory postsynpatic currents in hippocampal dentate granule cells is reduced compared to in wild-type cells

• isoflurane treatment induced a reduced percentage change in decay time constant in hippocampal dentate granule cells compared to in wild-type cells