Phenotypes Associated with This Genotype

Genotype
MGI:5002450

• Allelic Composition: Mecp2^tm1.1Vnar/Mecp2^tm1.1Vnar
• Genetic Background: B6N.129-Mecp2^tm1.1Vnar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:171411 )

♀N • mice live longer than 14 months with no unusual health issues

reproductive system

male infertility ( J:171411 )

♂ • mice do not successfully reproduce

behavior/neurological

behavior/neurological phenotype ( J:171411 )

♀N • mice do not exhibit seizures or tremors

nervous system

abnormal hippocampus morphology ( J:171411 )

♀ • cell density in the CA1, CA2, and CA3 of the hippocampus is increased compared to in wild-type mice

abnormal dentate gyrus morphology ( J:171411 )

♀ • cell density in the dentate gyrus is increased compared to in wild-type mice

abnormal orbitofrontal cortex morphology ( J:171411 )

♀ • cell density in the frontal cortex is increased compared to in wild-type mice

abnormal olfactory bulb morphology ( J:171411 )

♀ • cell density in the olfactory bulb is increased compared to in wild-type mice

abnormal cerebellum morphology ( J:171411 )

♀ • cell density in the cerebellum is increased compared to in wild-type mice

abnormal cerebellar granule layer morphology ( J:171411 )

♀ • cell density in the granule cell layer of the cerebellum is increased compared to in wild-type mice

abnormal dendrite morphology ( J:171411 )

♀ • cortical neurons exhibit abnormal dendritic branching and decreased dendritic complexity compared with wild-type neurons

growth/size/body

growth/size/body region phenotype ( J:171411 )

♀N • mice exhibit normal weight gain