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Phenotypes Associated with This Genotype
Genotype
MGI:5000479
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)#Tfln/0
Trp53tm1Brn/Trp53+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (313 available)
Tg(MMTV-cre)#Tfln mutation (0 available)
Trp53tm1Brn mutation (3 available); any Trp53 mutation (139 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan

endocrine/exocrine glands
• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan

mortality/aging
• survival is reduced compared to mutant mice wild-type for Trp53

neoplasm
• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
• at a lower rate than in mutant mice homozygous for Trp53tm1Brn

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:170898


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory