Mouse Genome Informatics
cn
    Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)4Mam/0

involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• survival is reduced compared to mutant mice wild-type for Trp53

tumorigenesis
• at a lower rate than in mutant mice homozygous for Trp53tm1Brn
• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:170898