Phenotypes for Gt(ROSA)26Sor Tg(MMTV-cre)#Tfln Trp53 MGI:5000478 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Tfln/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan} mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(MMTV-cre)#Tfln mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170898 )

• most die early with lymphoma/thymoma

neoplasm

increased mammary gland tumor incidence ( J:170898 )

• some mice have small mammary tumors

increased lymphoma incidence ( J:170898 )

increased T cell derived lymphoma incidence ( J:170898 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170898 )

• some mice have small mammary tumors

increased T cell derived lymphoma incidence ( J:170898 )

integument

increased mammary gland tumor incidence ( J:170898 )

• some mice have small mammary tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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