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Phenotypes Associated with This Genotype
Genotype
MGI:5000475
Allelic
Composition		 Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:170898 )
• decreased survival compared to wild-type controls carrying either Tg(MMTV-cre)1Mam or Tg(MMTV-cre)4Mam

cardiovascular system
abnormal blood vessel morphology ( J:170898 )
• some mice develop blood vessel lesions

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory