Phenotypes Associated with This Genotype

Genotype
MGI:5000442

• Allelic Composition: Cd19^tm1Tft/Cd19^tm1Tft
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation

decreased B cell number ( J:71174 )

• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice but less significantly than in Lyn^tm1Sor homozygotes

decreased B-1 B cell number ( J:71174 )

abnormal humoral immune response ( J:71174 )

• mice exhibit impaired primary and secondary IgM responses compared with wild-type mice

• after second immunization, mice exhibit modest IgG1 anti-DNP responses compared with wild-type mice

decreased IgA level ( J:71174 )

decreased IgG1 level ( J:71174 )

decreased IgG2b level ( J:71174 )

decreased IgM level ( J:71174 )

hematopoietic system

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation

decreased B cell number ( J:71174 )

• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice but less significantly than in Lyn^tm1Sor homozygotes

decreased B-1 B cell number ( J:71174 )

decreased IgA level ( J:71174 )

decreased IgG1 level ( J:71174 )

decreased IgG2b level ( J:71174 )

decreased IgM level ( J:71174 )

cellular

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation